Research Articles
Multivariate Analysis of Neurochemical Data: From Foundational Concepts to Clinical Applications in Biomarker Discovery and Drug Development
This comprehensive review explores multivariate analysis (MVA) techniques for neurochemical data, addressing the critical need to analyze complex, interacting variables in neuroscience research.
Real-Time Neurochemical Monitoring: Advanced Electrochemical Techniques for Neuroscience Research and Drug Development
This comprehensive review explores cutting-edge electrochemical techniques revolutionizing real-time neurochemical monitoring for neuroscience research and pharmaceutical development.
Genetically Encoded Dopamine Sensors: A Comprehensive Guide for Neuroscience Research and Drug Development
This article provides a comprehensive overview of genetically encoded fluorescent sensors for dopamine imaging, a revolutionary technology enabling high-resolution analysis of neurochemical dynamics.
Advanced Microdialysis Protocols for Extracellular Neurotransmitter Sampling: A Comprehensive Guide for Preclinical Research
This article provides a comprehensive guide to in vivo microdialysis for sampling neurotransmitters in the brain extracellular space.
Closed-Loop Deep Brain Stimulation for Parkinson's Disease: Mechanisms, Clinical Translation, and Future Directions
Closed-loop deep brain stimulation (aDBS) represents a paradigm shift in the treatment of Parkinson's disease (PD), moving from continuous, open-loop stimulation to dynamic, biomarker-driven neuromodulation.
Magnetic Resonance Spectroscopy for Glutamate Quantification: Techniques, Applications, and Best Practices for CNS Research
This article provides a comprehensive resource for researchers and drug development professionals on in vivo glutamate quantification using proton magnetic resonance spectroscopy (¹H-MRS).
Illuminating the Brain: A Comprehensive Guide to Protein-Based Fluorescent Probes for Neurotransmitter Imaging
This article provides a comprehensive overview of the development, application, and future of protein-based fluorescent probes for imaging neurotransmitters.
Fast-Scan Cyclic Voltammetry for Adenosine Detection: Principles, Advances, and Clinical Translation
This article provides a comprehensive resource for researchers and drug development professionals on the application of Fast-Scan Cyclic Voltammetry (FSCV) for detecting the neuromodulator adenosine.
Combined fMRI-MRS: A Revolutionary Tool for Direct Neurochemical Measurement in Neuroscience and Drug Development
This article explores the transformative potential of combined functional Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy (fMRI-MRS), a novel neuroimaging method that enables the simultaneous acquisition of hemodynamic (BOLD-fMRI) and...
Neurotransmitter-Controlled Steroid Hormone Receptors in the CNS: Mechanisms, Methods, and Therapeutic Targeting
This article synthesizes current knowledge on the intricate crosstalk between neurotransmitters and steroid hormone receptors in the central nervous system, a rapidly advancing field with profound implications for neuropharmacology and...