Research Articles
Stimulus Intensity and Neurochemical Dynamics: An MRS Guide for Researchers and Drug Developers
This article synthesizes current research on how variations in stimulus intensity modulate MRS-visible neurochemical concentrations, with a focus on glutamate, GABA, and myo-inositol.
Linking Neurochemistry to Hemodynamics: A Comprehensive Analysis of BOLD Signal and Glutamate Concentration Correlation
This article synthesizes current research on the correlation between Blood-Oxygen-Level-Dependent (BOLD) functional MRI signals and glutamate concentration dynamics in the human brain.
Mitigating the Reproducibility Crisis in Neuroimaging Machine Learning: A Framework for Robust and Clinically Actionable Research
The integration of machine learning (ML) with neuroimaging data holds transformative potential for understanding and diagnosing psychiatric and neurological disorders.
Overcoming Spectral Overlap: Advanced Strategies for Multianalyte Neurochemical Detection
This article provides a comprehensive resource for researchers and drug development professionals tackling the critical challenge of spectral overlap in multianalyte neurochemical detection.
Optimizing Binding Kinetics for Fluorescent Neurotransmitter Probes: A Guide for Precision Neurochemical Sensing
This article provides a comprehensive guide for researchers and drug development professionals on optimizing the binding kinetics of fluorescent neurotransmitter probes.
Correcting Partial Volume Effects in MRS Voxel Placement: A Foundational Guide for Accurate Metabolite Quantification
This article provides a comprehensive guide for researchers and drug development professionals on addressing the critical challenge of partial volume effects (PVE) in Magnetic Resonance Spectroscopy (MRS).
Robust Statistical Methods for Small-Sample Neurochemical Studies: Enhancing Power, Validation, and Reproducibility
Small sample sizes are a prevalent challenge in neurochemical and neuroscience research, often leading to low statistical power, inflated effect sizes, and reduced reproducibility.
Optimizing Signal-to-Noise Ratio in Functional MRS: Advanced Coil Combination and Protocol Strategies for Researchers
This article provides a comprehensive guide for researchers and drug development professionals on optimizing the signal-to-noise ratio (SNR) in functional Magnetic Resonance Spectroscopy (MRS), a critical factor for reliable metabolite...
Optimizing 7T MR Spectroscopy: Advanced Data Acquisition Parameters for Precision Neuroimaging and Biomarker Discovery
Ultra-high-field 7Tesla Magnetic Resonance Spectroscopy (MRS) offers unprecedented opportunities for non-invasive metabolic profiling in biomedical research and drug development.
Strategies for Reducing Variance in Neuroimaging Classification Models: Enhancing Reproducibility for Clinical and Research Applications
This article provides a comprehensive guide for researchers and drug development professionals on managing variability in neuroimaging-based classification models.