Research Articles
The Small-n-Large-p Problem in Neuroimaging: Overcoming High-Dimensional Data Challenges for Accurate Brain Classification
This article addresses the critical 'small-n-large-p' problem in neuroimaging classification, where the number of features (p, e.g., voxels) vastly exceeds the number of subjects (n).
Decoding Brain Heterogeneity: How HYDRA Clustering Maps Cortical Structural Deviations in Major Depressive Disorder
Major Depressive Disorder (MDD) exhibits significant clinical and neurobiological heterogeneity, challenging diagnosis and treatment.
HPLC-ECD for Monoamine Analysis in Microdialysis: A Comprehensive Guide from Fundamentals to Advanced Applications
This article provides a comprehensive guide to High-Performance Liquid Chromatography with Electrochemical Detection (HPLC-ECD) for the analysis of monoamine neurotransmitters in microdialysates.
Decoding Parkinson's: Advanced HPLC Methods for CSF Neurotransmitter Profiling in Clinical Research
This article provides a comprehensive guide for researchers and drug development professionals on the application of High-Performance Liquid Chromatography (HPLC) for analyzing cerebrospinal fluid (CSF) neurotransmitters in Parkinson's disease (PD).
HPA Axis Suppression Management: Strategies, Biomarkers, and Novel Therapeutics in Corticosteroid Therapy
This article provides a comprehensive analysis for researchers, scientists, and drug development professionals on managing hypothalamic-pituitary-adrenal (HPA) axis suppression in corticosteroid treatment.
The HPA Axis in Psychopathology: A Systematic Meta-Analysis of Stress Response Patterns in Schizophrenia vs. Major Depression
This meta-analysis systematically examines and compares hypothalamic-pituitary-adrenal (HPA) axis activity in schizophrenia and major depressive disorder (MDD), two major psychiatric conditions with overlapping and distinct pathophysiological features.
HPA Axis Dysregulation in Depression: A Comprehensive Analysis of Reactivity Differences and Biomarker Potential
This review synthesizes current research comparing Hypothalamic-Pituitary-Adrenal (HPA) axis reactivity between healthy individuals and patients with Major Depressive Disorder (MDD).
The Neuroimmune Vicious Cycle: Unraveling HPA Axis Dysfunction and Microglial Activation in Disease Pathogenesis
This review synthesizes current research on the bidirectional relationship between Hypothalamic-Pituitary-Adrenal (HPA) axis dysfunction and microglial activation, a core mechanism in neuropsychiatric and neurodegenerative disorders.
Targeting HPA Axis Dysfunction: Advanced Therapeutic Strategies for Chronic Stress Disorders in Drug Development
This article provides a comprehensive review for researchers and drug development professionals on therapeutic approaches for chronic stress-induced Hypothalamic-Pituitary-Adrenal (HPA) axis dysfunction.
The Developing HPA Axis: Molecular Mechanisms, Sex Differences, and Translational Implications
This review synthesizes current research on the Hypothalamic-Pituitary-Adrenal (HPA) axis development and its profound sexual dimorphism.