Research Articles
D1 vs. D2 Dopamine Receptors: Distinct Molecular Mechanisms and Behavioral Functions in Reward Processing
This review synthesizes current research on the distinct and often opposing roles of dopamine D1- and D2-like receptors in reward-related behaviors.
Cross-Validation in Neuroimaging ML: A Complete Guide to Protocols, Pitfalls, and Best Practices for Research
This comprehensive guide examines cross-validation (CV) protocols for neuroimaging machine learning, addressing critical challenges like data leakage, site/scanner bias, and small sample sizes.
Linear vs. Non-Linear Classifiers in Neuroimaging: A Practical Guide for Brain Data Analysis and Biomarker Discovery
This comprehensive guide explores the critical choice between linear and non-linear classifiers for analyzing neuroimaging data, a cornerstone of modern neuroscience and psychiatric drug development.
Neuroimaging Classification Accuracy: A Cross-Validation Framework for Model Comparison and Clinical Translation
This article provides a comprehensive guide for researchers and drug development professionals on evaluating and comparing the accuracy of neuroimaging classification models using cross-validation.
Deep Learning vs. Traditional Machine Learning in Drug Discovery: A Comprehensive Performance Guide for Researchers
This article provides a detailed comparative analysis of deep learning (DL) and traditional machine learning (TML) methodologies within biomedical research and drug development.
Filter vs Wrapper Feature Selection: A Comprehensive Guide for Biomedical Research and Drug Development
This article provides a comparative analysis of filter and wrapper feature selection methods, tailored for researchers and drug development professionals.
CSTC Circuit Dopamine Dysregulation in OCD: Mechanisms, Models, and Therapeutic Implications
This comprehensive review synthesizes current research on the role of cortico-striatal-thalamo-cortical (CSTC) circuit dopamine dysregulation in the pathophysiology of obsessive-compulsive disorder (OCD).
Beyond Diagnosis: Leveraging CSF Biomarkers to Track and Predict Parkinson's Disease Progression
This article provides a comprehensive review for researchers and drug development professionals on the role of cerebrospinal fluid (CSF) biomarkers in monitoring Parkinson's disease (PD) progression.
Chronic Stress Models Decoded: A Comparative Analysis of CSDS, CUMS, and Restraint Stress for Preclinical Research
This comprehensive guide provides researchers and drug development professionals with a critical comparison of three predominant preclinical chronic stress models: Chronic Social Defeat Stress (CSDS), Chronic Unpredictable Mild Stress (CUMS),...
CRH and Urocortin Receptor Binding Assays: A Comprehensive Guide for Neuroendocrine Research and Drug Discovery
This comprehensive guide explores the critical role of Corticotropin-Releasing Hormone (CRH) and urocortin (UCN) receptor binding assays in modern neuroendocrine research and pharmaceutical development.