Research Articles
Decoding the Brain's Language: How the fMRI BOLD Signal Reflects Synaptic Activity for Research and Drug Discovery
This article provides a comprehensive resource for researchers, neuroscientists, and drug development professionals on the critical link between the Blood-Oxygen-Level-Dependent (BOLD) fMRI signal and underlying synaptic activity.
Decoding Brain Activity: The Critical Correlation Between BOLD fMRI, LFP, and Glutamate Signaling for Neurological Research
This article provides a comprehensive analysis for researchers and drug development professionals on the relationship between the Blood-Oxygen-Level-Dependent (BOLD) fMRI signal, Local Field Potentials (LFP), and glutamate-mediated neurotransmission.
Unlocking Metabolic Insights: The Critical Role of BOLD Correlation with Glx vs. Glutamate in Neuroimaging Research
This article explores the critical distinction between BOLD fMRI correlation with the combined glutamate-glutamine marker (Glx) versus its isolated precursor, glutamate, for researchers and drug development professionals.
A Practical Guide to BIDS for Neurochemical ML: Standardizing Data to Unlock Discovery
This article provides a comprehensive guide for researchers and drug development professionals on applying the Brain Imaging Data Structure (BIDS) standard to neurochemical data for machine learning.
Maximizing MRS Signal Integrity: A Comprehensive Guide to Advanced B0 Shimming Techniques for Researchers
This article provides a comprehensive overview of B0 shimming techniques essential for optimizing Magnetic Resonance Spectroscopy (MRS) signal quality.
Beyond the Hype: A Practical Guide to Combat p-Hacking in Neuroimaging ML Studies for Robust Biomarker Discovery
This article provides a comprehensive guide for researchers and industry professionals on identifying, preventing, and correcting p-hacking in neuroimaging machine learning.
AMPA vs NMDA Receptors in Visual Processing: Decoding Their Distinct Roles for Research and Drug Development
This article provides a comprehensive, research-focused analysis of the distinct and complementary contributions of AMPA and NMDA-type glutamate receptors to visual information processing.
Decoding Brain Signals: A Comprehensive Review of Electrophysiological Biomarkers for ALIC DBS in Treatment-Resistant OCD
Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an established intervention for severe, treatment-refractory obsessive-compulsive disorder (OCD).
AAV Delivery for Biosensors: A Complete Guide to Viral Vector Strategies, Optimization & In Vivo Application
This article provides a comprehensive overview of adeno-associated virus (AAV)-mediated delivery for genetically encoded biosensors, targeting researchers and drug development professionals.
7T vs 3T MRS for Glutamate Detection: Quantifying Sensitivity Gains for Research & Drug Development
This article provides a comprehensive analysis of Magnetic Resonance Spectroscopy (MRS) for glutamate detection, comparing the sensitivity and practical utility of 3T and 7T systems.