Research Articles
Closed-Loop Deep Brain Stimulation for Parkinson's Disease: Mechanisms, Clinical Translation, and Future Directions
Closed-loop deep brain stimulation (aDBS) represents a paradigm shift in the treatment of Parkinson's disease (PD), moving from continuous, open-loop stimulation to dynamic, biomarker-driven neuromodulation.
Magnetic Resonance Spectroscopy for Glutamate Quantification: Techniques, Applications, and Best Practices for CNS Research
This article provides a comprehensive resource for researchers and drug development professionals on in vivo glutamate quantification using proton magnetic resonance spectroscopy (¹H-MRS).
Illuminating the Brain: A Comprehensive Guide to Protein-Based Fluorescent Probes for Neurotransmitter Imaging
This article provides a comprehensive overview of the development, application, and future of protein-based fluorescent probes for imaging neurotransmitters.
Fast-Scan Cyclic Voltammetry for Adenosine Detection: Principles, Advances, and Clinical Translation
This article provides a comprehensive resource for researchers and drug development professionals on the application of Fast-Scan Cyclic Voltammetry (FSCV) for detecting the neuromodulator adenosine.
Combined fMRI-MRS: A Revolutionary Tool for Direct Neurochemical Measurement in Neuroscience and Drug Development
This article explores the transformative potential of combined functional Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy (fMRI-MRS), a novel neuroimaging method that enables the simultaneous acquisition of hemodynamic (BOLD-fMRI) and...
Neurotransmitter-Controlled Steroid Hormone Receptors in the CNS: Mechanisms, Methods, and Therapeutic Targeting
This article synthesizes current knowledge on the intricate crosstalk between neurotransmitters and steroid hormone receptors in the central nervous system, a rapidly advancing field with profound implications for neuropharmacology and...
Neural Control of Muscle Neurochemistry: From Molecular Mechanisms to Therapeutic Innovation
This article synthesizes contemporary research on the intricate biochemical crosstalk between the nervous system and muscle tissue.
Decoding Dopine Signaling: Neural Circuits, Reward Mechanisms, and Therapeutic Frontiers
This comprehensive review synthesizes current research on dopamine signaling pathways and their pivotal role in reward processing, motivation, and adaptive behavior.
Microglial Activation in Mental Disorders: From Neuroinflammatory Mechanisms to Novel Therapeutic Strategies
This review synthesizes current research on the pivotal role of microglial activation and neuroinflammation in the pathophysiology of mental disorders.
HPA Axis Dysregulation and Neuroendocrine Interactions: From Molecular Mechanisms to Therapeutic Interventions in Stress Pathophysiology
This comprehensive review synthesizes current research on the hypothalamic-pituitary-adrenal (HPA) axis as the central regulator of the stress response and its complex interactions with other neuroendocrine systems.