Research Articles
Protein-Based vs Synthetic Fluorescent Probes in Neurochemistry: A Comprehensive Guide for Researchers and Drug Developers
This article provides a comparative analysis of protein-based and synthetic fluorescent probes, essential tools for visualizing neurochemical dynamics in live cells and brain tissue.
Combating Biofouling in Electrochemical Neurochemical Sensors: Strategies for Long-Term Stability and Accurate In Vivo Monitoring
This article addresses the critical challenge of biofouling in electrochemical neurochemical sensors, a major obstacle to reliable long-term in vivo monitoring for neuroscience research and drug development.
Dopamine and Beyond: The Neurochemical Basis of Parkinson's Motor Symptoms and Therapeutic Implications
This article provides a comprehensive analysis of the neurochemical mechanisms underlying Parkinson's disease (PD) motor symptoms, tailored for researchers and drug development professionals.
Beyond Serotonin: Mapping Glutamate, GABA, and Dopamine Dysregulation in Obsessive-Compulsive Disorder
This article provides a comprehensive synthesis of current research on neurotransmitter dysregulation in Obsessive-Compulsive Disorder (OCD), moving beyond the traditional serotonin hypothesis.
Electrophysiological vs. Neurochemical Biomarkers for Deep Brain Stimulation: A Scientific Review for Researchers and Developers
This article provides a comprehensive analysis of two pivotal classes of biomarkers for Deep Brain Stimulation (DBS): electrophysiological and neurochemical.
Serotonin Receptor Subtypes in Emotional Regulation: From Molecular Mechanisms to Translational Therapeutics
This article synthesizes current research on serotonin receptor subtypes and their critical role in emotional regulation, a key focus for developing novel neuropsychiatric treatments.
A Practical Guide to Cross-Validation for Robust and Reproducible Neurochemical Data Analysis
This article provides a comprehensive guide to implementing cross-validation (CV) in neurochemical data analysis, addressing critical challenges from foundational principles to advanced validation techniques.
Cross-Validation Methods for Robust Machine Learning Model Comparison in Biomedical Research
This article provides a comprehensive guide to cross-validation methodologies for rigorously comparing and selecting machine learning models, with a specific focus on applications in drug development and clinical research.
Microdialysis vs. FSCV for Adenosine Measurement: A Comprehensive Technical Guide for Neuroscientists and Drug Developers
This article provides a comparative analysis of microdialysis and Fast-Scan Cyclic Voltammetry (FSCV) for measuring extracellular adenosine in the brain.
Excitation and Inhibition in Sight: How GABA and Glutamate Orchestrate Visual Processing
This article synthesizes current research on the distinct yet interdependent roles of the inhibitory neurotransmitter GABA and the excitatory neurotransmitter glutamate in visual processing.