Research Articles
Beyond Serotonin: Mapping Glutamate, GABA, and Dopamine Dysregulation in Obsessive-Compulsive Disorder
This article provides a comprehensive synthesis of current research on neurotransmitter dysregulation in Obsessive-Compulsive Disorder (OCD), moving beyond the traditional serotonin hypothesis.
Electrophysiological vs. Neurochemical Biomarkers for Deep Brain Stimulation: A Scientific Review for Researchers and Developers
This article provides a comprehensive analysis of two pivotal classes of biomarkers for Deep Brain Stimulation (DBS): electrophysiological and neurochemical.
Serotonin Receptor Subtypes in Emotional Regulation: From Molecular Mechanisms to Translational Therapeutics
This article synthesizes current research on serotonin receptor subtypes and their critical role in emotional regulation, a key focus for developing novel neuropsychiatric treatments.
A Practical Guide to Cross-Validation for Robust and Reproducible Neurochemical Data Analysis
This article provides a comprehensive guide to implementing cross-validation (CV) in neurochemical data analysis, addressing critical challenges from foundational principles to advanced validation techniques.
Cross-Validation Methods for Robust Machine Learning Model Comparison in Biomedical Research
This article provides a comprehensive guide to cross-validation methodologies for rigorously comparing and selecting machine learning models, with a specific focus on applications in drug development and clinical research.
Microdialysis vs. FSCV for Adenosine Measurement: A Comprehensive Technical Guide for Neuroscientists and Drug Developers
This article provides a comparative analysis of microdialysis and Fast-Scan Cyclic Voltammetry (FSCV) for measuring extracellular adenosine in the brain.
Excitation and Inhibition in Sight: How GABA and Glutamate Orchestrate Visual Processing
This article synthesizes current research on the distinct yet interdependent roles of the inhibitory neurotransmitter GABA and the excitatory neurotransmitter glutamate in visual processing.
Validating Neurochemical-Enriched Dynamic Causal Models: A New Frontier for CNS Drug Development
This article explores the validation of neurochemical-enriched Dynamic Causal Models (DCMs), a transformative computational approach that integrates neurochemical data with neural circuit models.
Rigorous Statistical Comparison of Neuroimaging Classification Models: A Framework for Accuracy Assessment and Reproducible Machine Learning
This article provides a comprehensive guide for researchers and drug development professionals on the rigorous statistical comparison of machine learning model accuracy in neuroimaging.
Closed-Loop vs. Open-Loop Deep Brain Stimulation: Efficacy, Mechanisms, and Future Directions in Neuromodulation
This article provides a comprehensive analysis of the efficacy of closed-loop (CL) versus open-loop (OL) deep brain stimulation (DBS) for neurological and psychiatric disorders.